Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine.
作者:
Nicola J,Wyatt [1]
;
Hannah,Watson [2]
;
Carl A,Anderson [3]
;
Nicholas A,Kennedy [4]
;
Tim,Raine [5]
;
Tariq,Ahmad [4]
;
Dean,Allerton [6]
;
Michelle,Bardgett [6]
;
Emma,Clark [6]
;
Dawn,Clewes [6]
;
Cristina,Cotobal Martin [3]
;
Mary,Doona [7]
;
Jennifer A,Doyle [2]
;
Katherine,Frith [6]
;
Helen C,Hancock [6]
;
Ailsa L,Hart [8]
;
Victoria,Hildreth [6]
;
Peter M,Irving [9]
;
Sameena,Iqbal [3]
;
Ciara,Kennedy [6]
;
Andrew,King [7]
;
Sarah,Lawrence [6]
;
Charlie W,Lees [10]
;
Robert,Lees [7]
;
Laura,Letchford [3]
;
Trevor,Liddle [11]
;
James O,Lindsay [12]
;
Rebecca H,Maier [6]
;
John C,Mansfield [1]
;
Julian R,Marchesi [13]
;
Naomi,McGregor [6]
;
Rebecca E,McIntyre [3]
;
Jasmin,Ostermayer [3]
;
Tolulope,Osunnuyi [3]
;
Nick,Powell [14]
;
Natalie J,Prescott [15]
;
Jack,Satsangi [16]
;
Shriya,Sharma [6]
;
Tara,Shrestha [6]
;
Ally,Speight [1]
;
Michelle,Strickland [3]
;
James Ms,Wason [17]
;
Kevin,Whelan [18]
;
Ruth,Wood [6]
;
Gregory R,Young [2]
;
Xinyue,Zhang [17]
;
Miles,Parkes [5]
;
Christopher J,Stewart [2]
;
Luke,Jostins-Dean [19]
;
Christopher A,Lamb [20]
作者单位:
Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.;Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
[1]
Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
[2]
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
[3]
Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.;Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.
[4]
Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
[5]
Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.
[6]
Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
[7]
Department of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.;Department of Surgery and Cancer, Imperial College London, London, UK.
[8]
Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK.;School of Immunology & Microbial Sciences, King's College London, London, UK.
[9]
Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.;Edinburgh IBD Unit, Western General Hospital, NHS Lothian, Edinburgh, UK.
[10]
Research Informatics Team, Clinical Research, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
[11]
Department of Gastroenterology, Barts Health NHS Trust, London, UK.;Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
[12]
Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK.
[13]
Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK.;Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK.
[14]
Department of Medical and Molecular Genetics, Guy's Hospital, King's College London, London, UK.
[15]
Nuffield Department of Medicine, University of Oxford, Oxford, UK.
[16]
Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
[17]
Department of Nutritional Sciences, King's College London, London, UK.
[18]
Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
[19]
Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK christopher.lamb@newcastle.ac.uk.;Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
[20]
主题词
人类(Humans);结肠炎, 溃疡性(Colitis, Ulcerative);Crohn病(Crohn Disease);炎性肠疾病(Inflammatory Bowel Diseases);多中心研究(主题)(Multicenter Studies as Topic);前瞻性研究(Prospective Studies);生活质量(Quality of Life)
DOI
10.1136/bmjopen-2023-073639
PMID
38631839
发布时间
2024-12-30
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BMJ open
BMJ open
e073639页
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