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Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors.

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作者单位: Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: suazo003@umn.edu. [1] Center for Motor Neuron Biology and Diseases, Department of Neurology. Columbia University Irving Medical Center. New York, NY 10032, USA; Department of Pathology & Cell Biology. Columbia University Irving Medical Center. New York, NY 10032, USA. Electronic address: vartikarmishra@gmail.com. [2] Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. [3] Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: auger054@umn.edu. [4] Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: kjustyna@umn.edu. [5] Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: petre096@umn.edu. [6] Department of Pathophysiology and Transplantation, Dino Ferrari Center, Università degli Studi di Milano, Milan, Italy. Electronic address: linda.ottoboni@unimi.it. [7] Neurology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. [8] Department of Pathophysiology and Transplantation, Dino Ferrari Center, Università degli Studi di Milano, Milan, Italy; Neurology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Neuromuscular and Rare Diseases Unit, Department of Neuroscience, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: stefania.corti@unimi.it. [9] Center for Motor Neuron Biology and Diseases, Department of Neurology. Columbia University Irving Medical Center. New York, NY 10032, USA; Department of Pathology & Cell Biology. Columbia University Irving Medical Center. New York, NY 10032, USA. Electronic address: fl2219@cumc.columbia.edu. [10] Center for Motor Neuron Biology and Diseases, Department of Neurology. Columbia University Irving Medical Center. New York, NY 10032, USA; Department of Pathology & Cell Biology. Columbia University Irving Medical Center. New York, NY 10032, USA; Department of Neuroscience, Pathology, and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: sp30@cumc.columbia.edu. [11] Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: diste001@umn.edu. [12]
DOI 10.1016/j.bioorg.2024.107365
PMID 38636436
发布时间 2025-01-04
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