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首页> Microvascular research> GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

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作者： Xiaoxiang,Xu ^[1] ; Xihui,Ding ^[1] ; Zizhuo,Wang ^[1] ; Shujiang,Ye ^[2] ; Jianguang,Xu ^[3] ; Zugang,Liang ^[4] ; Renfei,Luo ^[1] ; Jinyong,Xu ^[1] ; Xiaohui,Li ^[5] ; Zhenhua,Ren ^[6]

作者单位： Department of Anatomy, Anhui Medical University, Hefei, Anhui 230032, China. ^[1] Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230012, China; Anhui Public Health Clinical Center, Hefei, Anhui 230012, China. ^[2] College and Hospital of Stomatology, Key Lab. of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, Anhui 230032, China. ^[3] Hefei Huaxia Mingren Eye Hospital, Hefei, Anhui 230032, China. ^[4] Department of Anatomy, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: 1292936941@qq.com. ^[5] Department of Anatomy, Anhui Medical University, Hefei, Anhui 230032, China; College and Hospital of Stomatology, Key Lab. of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: renzhenhua1975@163.com. ^[6]

关键词 Guanylate-binding protein 2 Pathologic angiogenesis Retinal neovascularization Vascular endothelial growth factor

主题词动物(Animals);人类(Humans);小鼠(Mice);细胞低氧(Cell Hypoxia);细胞系(Cell Line);疾病模型, 动物(Disease Models, Animal);GTP结合蛋白质类(GTP-Binding Proteins);小鼠, 近交C57BL(Mice, Inbred C57BL);氧(Oxygen);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);视网膜新生血管化(Retinal Neovascularization);视网膜色素上皮(Retinal Pigment Epithelium);视网膜血管(Retinal Vessels);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);血管内皮生长因子A(Vascular Endothelial Growth Factor A)

DOI 10.1016/j.mvr.2024.104689

PMID 38636926

发布时间 2024-07-05

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Microvascular research

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