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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.

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第一作者： Ayumi E,Pottenger

第一单位： Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

作者： Ayumi E,Pottenger ^[1] ; Debashish,Roy ^[1] ; Selvi,Srinivasan ^[1] ; Thomas E J,Chavas ^[1] ; Vladmir,Vlaskin ^[1] ; Duy-Khiet,Ho ^[1] ; Vincent C,Livingston ^[1] ; Mahdi,Maktabi ^[2] ; Hsiuling,Lin ^[3] ; Jing,Zhang ^[3] ; Brandon,Pybus ^[3] ; Karl,Kudyba ^[3] ; Alison,Roth ^[3] ; Peter,Senter ^[4] ; George,Tyson ^[5] ; Hans E,Huber ^[6] ; David,Wesche ^[7] ; Rosemary,Rochford ^[2] ; Paul A,Burke ^[8] ; Patrick S,Stayton ^[1]

作者单位： Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. ^[1] Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA. ^[2] Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. ^[3] Seagen, Bothell, WA 98021, USA. ^[4] George Tyson Consulting, Los Altos Hills, CA 94022, USA.;Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA. ^[5] BioTD Strategies LLC, 213 Abbey Ln., Lansdale, PA 19446, USA. ^[6] Certara, Princeton, NJ 08540, USA. ^[7] Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.;Burke Bioventures LLC, 1 Broadway 14th Floor, Cambridge, MA 02142, USA. ^[8]

医学主题词人类(Humans);抗疟药(Antimalarials);氨基喹啉类(Aminoquinolines);疟疾(Malaria);疟疾, 间日(Malaria, Vivax);肝(Liver)

DOI 10.1126/sciadv.adk4492

PMID 38640243

发布时间 2025-06-18

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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.

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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.

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