QDPR deficiency drives immune suppression in pancreatic cancer.

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第一作者： Ji,Liu

第一单位： Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China and Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.

作者： Ji,Liu ^[1] ; Xiaowei,He ^[1] ; Shuang,Deng ^[1] ; Sihan,Zhao ^[1] ; Shaoping,Zhang ^[1] ; Ziming,Chen ^[1] ; Chunling,Xue ^[1] ; Lingxing,Zeng ^[1] ; Hongzhe,Zhao ^[1] ; Yifan,Zhou ^[1] ; Ruihong,Bai ^[1] ; Zilan,Xu ^[1] ; Shaoqiu,Liu ^[1] ; Quanbo,Zhou ^[2] ; Mei,Li ^[3] ; Jialiang,Zhang ^[1] ; Xudong,Huang ^[1] ; Rufu,Chen ^[4] ; Liqin,Wang ^[5] ; Dongxin,Lin ^[6] ; Jian,Zheng ^[7]

作者单位： Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China and Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China. ^[1] Department of Pancreaticobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. ^[2] Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China. ^[3] Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China. ^[4] Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China and Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. Electronic address: wanglq1@sysucc.org.cn. ^[5] Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China and Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China; Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. Electronic address: lindx@cicams.ac.cn. ^[6] Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China and Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China. Electronic address: zhengjian@sysucc.org.cn. ^[7]

关键词 BH2 BH4 Cxcl1 ICB resistance MDSCs PDAC QDPR biopterin metabolism immune suppression