Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation.

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作者： Chen,Wang ^[1] ; Qiao,Chu ^[1] ; Wenxiao,Dong ^[1] ; Xin,Wang ^[1] ; Wenjing,Zhao ^[1] ; Xin,Dai ^[1] ; Wentian,Liu ^[1] ; Bangmao,Wang ^[1] ; Tianyu,Liu ^[2] ; Weilong,Zhong ^[3] ; Changtao,Jiang ^[4] ; Hailong,Cao ^[5]

作者单位： Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China. ^[1] Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China. Electronic address: liutianyu@tmu.edu.cn. ^[2] Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China. Electronic address: zhongweilong@tmu.edu.cn. ^[3] Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China. Electronic address: jiangchangtao@bjmu.edu.cn. ^[4] Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China. Electronic address: caohailong@tmu.edu.cn. ^[5]

关键词 Byak-angelicin Colitis Deoxycholic acid Ferroptosis HIF-2α/DMT1 High-fat diet

主题词动物(Animals);脱氧胆酸(Deoxycholic Acid);小鼠(Mice);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);人类(Humans);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);炎症(Inflammation);结肠炎(Colitis);结肠(Colon);结肠炎, 溃疡性(Colitis, Ulcerative);小鼠, 基因敲除(Mice, Knockout)

DOI 10.1016/j.molmet.2024.101944

PMID 38642891

发布时间 2024-05-22

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Molecular metabolism

2024年84卷

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Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation.

Molecular metabolism

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Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation.

Molecular metabolism

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Molecular metabolism

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