GDF9<sup>His209GlnfsTer6/S428T</sup> and GDF9<sup>Q321X/S428T</sup> bi-allelic variants caused female subfertility with defective follicle enlargement.

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作者： Yuwei,Duan ^[1] ; Bing,Cai ^[2] ; Jing,Guo ^[3] ; Chen,Wang ^[1] ; Qingyun,Mai ^[2] ; Yan,Xu ^[3] ; Yang,Zeng ^[1] ; Yue,Shi ^[2] ; Boyan,Wang ^[3] ; Chenhui,Ding ^[1] ; Minghui,Chen ^[2] ; Canquan,Zhou ^[3] ; Yanwen,Xu ^[1]

作者单位： Department of Gynecology & Obstetrics, Center for Reproductive Medicine, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China. ^[1] Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, Guangdong, 510080, China. ^[2] Guangdong Provincial Clinical Research Center for obstetrical and gynecological diseases, Guangzhou, Guangdong, 510080, China. ^[3] Department of Gynecology & Obstetrics, Center for Reproductive Medicine, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China. xuyanwen@mail.sysu.edu.cn. ^[4] Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, Guangdong, 510080, China. xuyanwen@mail.sysu.edu.cn. ^[5] Guangdong Provincial Clinical Research Center for obstetrical and gynecological diseases, Guangzhou, Guangdong, 510080, China. xuyanwen@mail.sysu.edu.cn. ^[6]

关键词 In vivo model Follicular enlargement GDF9 Poor ovarian response Steroidogenesis