Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders.

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作者： Lucía,Rodríguez-Pombo ^[1] ; María José,de Castro-López ^[2] ; Paula,Sánchez-Pintos ^[2] ; Jose Maria,Giraldez-Montero ^[3] ; Patricija,Januskaite ^[4] ; Goretti,Duran-Piñeiro ^[3] ; M,Dolores Bóveda ^[2] ; Carmen,Alvarez-Lorenzo ^[1] ; Abdul W,Basit ^[5] ; Alvaro,Goyanes ^[6] ; Maria L,Couce ^[7]

作者单位： Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Materials Institute iMATUS and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. ^[1] Servicio de Neonatología, Unidad de Diagnóstico y Tratamiento de Enfermedades Metabólicas Congénitas, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, Universidad de Santiago de Compostela, IDIS, RICORS, CIBERER, MetabERN, Spain. ^[2] Pharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela 15706, Spain. ^[3] Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. ^[4] Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FABRX Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, UK; FABRX Artificial Intelligence, Carretera de Escairón, 14, Currelos (O Saviñao), CP 27543, Spain. ^[5] Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Materials Institute iMATUS and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain; Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FABRX Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, UK; FABRX Artificial Intelligence, Carretera de Escairón, 14, Currelos (O Saviñao), CP 27543, Spain. Electronic address: a.goyanes@fabrx.co.uk. ^[6] Servicio de Neonatología, Unidad de Diagnóstico y Tratamiento de Enfermedades Metabólicas Congénitas, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, Universidad de Santiago de Compostela, IDIS, RICORS, CIBERER, MetabERN, Spain. Electronic address: maria.luz.couce.pico@sergas.es. ^[7]

关键词 Additive manufacturing of drug products Direct ink writing Patient acceptability of formulations Pediatrics Polypills Precision pharmaceuticals and drug delivery systems Semi-solid extrusion 3D printing