Discovery of an Ortho-Substituted <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-<i>endo</i>ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect.

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作者： Zixiang,Li ^[1] ; Rufeng,Ye ^[2] ; Qian,He ^[3] ; Jiashuo,Lu ^[1] ; Yanting,Sun ^[2] ; Xiujian,Sun ^[4] ; Siyuan,Tang ^[5] ; Shuyang,Hu ^[5] ; Jingrui,Chai ^[1] ; Linghui,Kong ^[2] ; Xiaoning,Liu ^[2] ; Jing,Chen ^[1] ; Yun,Fang ^[6] ; Yingjie,Lan ^[2] ; Qiong,Xie ^[1] ; Jinggen,Liu ^[1] ; Liming,Shao ^[1] ; Wei,Fu ^[2] ; Yujun,Wang ^[3] ; Wei,Li ^[5]

作者单位： Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China. ^[1] CAS Key Laboratory of Receptor Research and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Shanghai 201203, China. ^[2] University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[3] Department of Pharmacy, Dalian Medical University, Dalian 116044, China. ^[4] Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurobiology of Zhejiang Province, Hangzhou 310053, China. ^[5] Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, Shandong, China. ^[6]