Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.

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第一作者： Serene W,Chen

第一单位： Downstream Processing Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore.

作者： Serene W,Chen ^[1] ; Kong Meng,Hoi ^[1] ; Farouq Bin,Mahfut ^[2] ; Yuansheng,Yang ^[2] ; Wei,Zhang ^[3]

作者单位： Downstream Processing Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore. ^[1] Cell Line Development Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore. ^[2] Downstream Processing Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore. zhang_wei@bti.a-star.edu.sg. ^[3]

关键词 Bispecific antibody Flow-through polishing High molecular weight impurities Higher aggregation propensity Host cell proteins Knob-into-hole Low molecular weight impurities

DOI 10.1186/s40643-022-00590-8

PMID 38647877

发布时间 2024-11-18

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Bioresources and bioprocessing

2022年9卷1期

98页

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Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.

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Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.

Bioresources and bioprocessing

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