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NSABP FB-10: a phase Ib/II trial evaluating ado-trastuzumab emtansine (T-DM1) with neratinib in women with metastatic HER2-positive breast cancer.

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第一作者： Samuel A,Jacobs

第一单位： NSABP Foundation, Pittsburgh, PA, USA. jacobssa1945@gmail.com.

作者： Samuel A,Jacobs ^[1] ; Ying,Wang ^[2] ; Jame,Abraham ^[3] ; Huichen,Feng ^[2] ; Alberto J,Montero ^[4] ; Corey,Lipchik ^[2] ; Melanie,Finnigan ^[2] ; Rachel C,Jankowitz ^[5] ; Mohamad A,Salkeni ^[6] ; Sai K,Maley ^[2] ; Shannon L,Puhalla ^[7] ; Fanny,Piette ^[8] ; Katie,Quinn ^[9] ; Kyle,Chang ^[9] ; Rebecca J,Nagy ^[9] ; Carmen J,Allegra ^[10] ; Kelly,Vehec ^[2] ; Norman,Wolmark ^[11] ; Peter C,Lucas ^[12] ; Ashok,Srinivasan ^[13] ; Katherine L,Pogue-Geile ^[2]

作者单位： NSABP Foundation, Pittsburgh, PA, USA. jacobssa1945@gmail.com. ^[1] NSABP Foundation, Pittsburgh, PA, USA. ^[2] NSABP Foundation, Pittsburgh, PA, USA.;Cleveland Clinic, Weston/Taussig Cancer Institute, Cleveland, OH, USA. ^[3] NSABP Foundation, Pittsburgh, PA, USA.;Cleveland Clinic, Weston/Taussig Cancer Institute, Cleveland, OH, USA.;University Hospitals/Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, USA. ^[4] NSABP Foundation, Pittsburgh, PA, USA.;University of Pittsburgh, Pittsburgh, PA, USA.;University of Pennsylvania Perelman School of Medicine, State College, PA, USA. ^[5] NSABP Foundation, Pittsburgh, PA, USA.;National Institutes of Health, Washington, DC, USA.;Virginia Cancer Specialists, Fairfax, VA, USA. ^[6] NSABP Foundation, Pittsburgh, PA, USA.;UPMC Hillman Cancer Center, Pittsburgh, PA, USA.;University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ^[7] International Drug Development Institute, Louvain-la-Neuve, Belgium. ^[8] Guardant Health, Redwood City, CA, USA. ^[9] NSABP Foundation, Pittsburgh, PA, USA.;University of Florida Health, Gainesville, FL, USA. ^[10] NSABP Foundation, Pittsburgh, PA, USA.;UPMC Hillman Cancer Center, Pittsburgh, PA, USA. ^[11] NSABP Foundation, Pittsburgh, PA, USA.;UPMC Hillman Cancer Center, Pittsburgh, PA, USA.;University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.;Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. ^[12] NSABP Foundation, Pittsburgh, PA, USA.;Autism Impact Fund, Pittsburgh, PA, USA. ^[13]

关键词 Clinical trial Metastatic breast cancer Neratinib?+?t-DM1 ctDNA HER2 amplification