Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism.

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第一作者： Piyarat,Siripoksup

第一单位： Diabetes & Metabolism Research Center.;Department of Physical Therapy and Athletic Training.

作者： Piyarat,Siripoksup ^[1] ; Guoshen,Cao ^[2] ; Ahmad A,Cluntun ^[2] ; J Alan,Maschek ^[3] ; Quentinn,Pearce ^[4] ; Marisa J,Brothwell ^[5] ; Mi-Young,Jeong ^[2] ; Hiroaki,Eshima ^[6] ; Patrick J,Ferrara ^[5] ; Precious C,Opurum ^[5] ; Ziad S,Mahmassani ^[7] ; Alek D,Peterlin ^[5] ; Shinya,Watanabe ^[5] ; Maureen A,Walsh ^[1] ; Eric B,Taylor ^[8] ; James E,Cox ^[9] ; Micah J,Drummond ^[7] ; Jared,Rutter ^[10] ; Katsuhiko,Funai ^[11]

作者单位： Diabetes & Metabolism Research Center.;Department of Physical Therapy and Athletic Training. ^[1] Diabetes & Metabolism Research Center.;Department of Biochemistry. ^[2] Metabolomics Core Research Facility.;Department of Nutrition & Integrative Physiology, and. ^[3] Metabolomics Core Research Facility. ^[4] Diabetes & Metabolism Research Center.;Department of Nutrition & Integrative Physiology, and. ^[5] Diabetes & Metabolism Research Center.;Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA. ^[6] Diabetes & Metabolism Research Center.;Department of Physical Therapy and Athletic Training.;Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA. ^[7] Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA. ^[8] Diabetes & Metabolism Research Center.;Department of Biochemistry.;Metabolomics Core Research Facility. ^[9] Diabetes & Metabolism Research Center.;Department of Biochemistry.;Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA. ^[10] Diabetes & Metabolism Research Center.;Department of Physical Therapy and Athletic Training.;Department of Biochemistry.;Department of Nutrition & Integrative Physiology, and.;Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA. ^[11]

关键词 Metabolism Mitochondria Skeletal muscle