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SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir.

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第一作者： Kanal,Singh

第一单位： National Institute of Allergy and Infectious Diseases, Bethesda.

作者： Kanal,Singh ^[1] ; Kevin,Rubenstein ^[2] ; Viviane,Callier ^[2] ; Katy,Shaw-Saliba ^[1] ; Adam,Rupert ^[3] ; Robin,Dewar ^[3] ; Sylvain,Laverdure ^[3] ; Helene,Highbarger ^[3] ; Perrine,Lallemand ^[3] ; Meei-Li,Huang ^[4] ; Keith R,Jerome ^[5] ; Reigran,Sampoleo ^[4] ; Margaret G,Mills ^[4] ; Alexander L,Greninger ^[4] ; Kavita,Juneja ^[6] ; Danielle,Porter ^[6] ; Constance A,Benson ^[7] ; Walla,Dempsey ^[1] ; Hana M,El Sahly ^[8] ; Chris,Focht ^[9] ; Nikolaus,Jilg ^[10] ; Catharine I,Paules ^[11] ; Rekha R,Rapaka ^[12] ; Timothy M,Uyeki ^[13] ; H,Clifford Lane ^[1] ; John,Beigel ^[1] ; Lori E,Dodd ^[1] ; Adaptive COVID-19 Treatment Trial (ACTT-1) Study Group Members

作者单位： National Institute of Allergy and Infectious Diseases, Bethesda. ^[1] Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research. ^[2] National Laboratory for Cancer Research, Frederick, Maryland. ^[3] Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington. ^[4] Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington.;Fred Hutchinson Cancer Center, Seattle, Washington. ^[5] Gilead Sciences, Inc, Foster City, California. ^[6] University of California San Diego. ^[7] Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas. ^[8] The Emmes Company, Rockville, Maryland. ^[9] Massachusetts General Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston. ^[10] Division of Infectious Diseases, Milton S. Hershey Medical Center, Penn State Health, Hershey, Pennsylvania. ^[11] Center for Vaccine Development and Global Health, School of Medicine, University of Maryland, Baltimore. ^[12] Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia. ^[13]

关键词 COVID-19 SARS-CoV-2 antiviral efficacy clinical trial remdesivir