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首页> European journal of medicinal chemistry> Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis.

Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis.

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作者： Gongshan,Ma ^[1] ; Xiaojin,Gao ^[1] ; Xin,Zhang ^[1] ; Haixia,Li ^[1] ; Zhiyuan,Geng ^[1] ; Jing,Gao ^[1] ; Shuxin,Yang ^[1] ; Zhiruo,Sun ^[1] ; Yuqi,Lin ^[1] ; Xiaomei,Wen ^[1] ; Qingguo,Meng ^[1] ; Leiming,Zhang ^[2] ; Yi,Bi ^[3]

作者单位： School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. ^[1] School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, 264003, PR China. Electronic address: zhangleiming2009@126.com. ^[2] School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address: beeyee_413@163.com. ^[3]

关键词 Anti-inflammatory activity Glucocorticoid receptor Ocotillol Sepsis Structure-activity relationship

主题词受体, 糖皮质激素(Receptors, Glucocorticoid);脓毒症(Sepsis);动物(Animals);NF-κB(NF-kappa B);小鼠(Mice);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);人类(Humans);分子结构(Molecular Structure);药物发现(Drug Discovery);男(雄)性(Male);剂量效应关系, 药物(Dose-Response Relationship, Drug);消炎药(Anti-Inflammatory Agents);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal)

DOI 10.1016/j.ejmech.2024.116427

PMID 38657479

发布时间 2024-05-15

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European journal of medicinal chemistry

116427页

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