Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.-论文-万方医学网

第一作者： Stephane,Ferretti

第一单位： Novartis BioMedical Research, Basel, Switzerland.

作者： Stephane,Ferretti ^[1] ; Jacques,Hamon ^[1] ; Ruben,de Kanter ^[1] ; Clemens,Scheufler ^[1] ; Rita,Andraos-Rey ^[1] ; Stephanie,Barbe ^[1] ; Elisabeth,Bechter ^[1] ; Jutta,Blank ^[1] ; Vincent,Bordas ^[1] ; Ernesta,Dammassa ^[1] ; Andrea,Decker ^[1] ; Noemi,Di Nanni ^[1] ; Marion,Dourdoigne ^[1] ; Elena,Gavioli ^[2] ; Marc,Hattenberger ^[1] ; Alisa,Heuser ^[1] ; Christelle,Hemmerlin ^[1] ; Jürgen,Hinrichs ^[1] ; Grainne,Kerr ^[1] ; Laurent,Laborde ^[1] ; Isabel,Jaco ^[1] ; Eloísa Jiménez,Núñez ^[3] ; Hans-Joerg,Martus ^[1] ; Cornelia,Quadt ^[1] ; Markus,Reschke ^[1] ; Vincent,Romanet ^[1] ; Fanny,Schaeffer ^[1] ; Joseph,Schoepfer ^[1] ; Maxime,Schrapp ^[1] ; Ross,Strang ^[1] ; Hans,Voshol ^[1] ; Markus,Wartmann ^[1] ; Sarah,Welly ^[1] ; Frédéric,Zécri ^[4] ; Francesco,Hofmann ^[3] ; Henrik,Möbitz ^[5] ; Marta,Cortés-Cros ^[6]

作者单位： Novartis BioMedical Research, Basel, Switzerland. ^[1] Novartis BioMedical Research, Basel, Switzerland.;Novartis Pharma AG, Basel, Switzerland. ^[2] Novartis BioMedical Research, Basel, Switzerland.;Pierre Fabre Laboratories, Toulouse, France. ^[3] Novartis BioMedical Research, Cambridge, MA, USA. ^[4] Novartis BioMedical Research, Basel, Switzerland. henrik.moebitz@novartis.com. ^[5] Novartis BioMedical Research, Basel, Switzerland. marta.cortes-cros@novartis.com. ^[6]

主题词动物(Animals);女(雌)性(Female);人类(Humans);小鼠(Mice);投药, 口服(Administration, Oral);别构调节(Allosteric Regulation);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);临床试验(主题)(Clinical Trials as Topic);结直肠肿瘤(Colorectal Neoplasms);DNA损伤(DNA Damage);药物发现(Drug Discovery);酶抑制剂(Enzyme Inhibitors);小鼠, 裸(Mice, Nude);微卫星不稳定性(Microsatellite Instability);肿瘤(Neoplasms);结果可重复性(Reproducibility of Results);抑制, 遗传(Suppression, Genetic);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/s41586-024-07350-y

PMID 38658754

发布时间 2024-06-05

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

Nature

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

Nature

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Nature

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