首页> European journal of medicinal chemistry> Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy.

Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy.

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第一作者： Digambar Kumar,Waiker

第一单位： Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology - Banaras Hindu University, Varanasi, 221005, India.

作者： Digambar Kumar,Waiker ^[1] ; Akash,Verma ^[1] ; T A,Gajendra ^[2] ; Namrata ^[3] ; Anima,Roy ^[3] ; Pradeep,Kumar ^[4] ; Surendra Kumar,Trigun ^[3] ; Saripella,Srikrishna ^[4] ; Sairam,Krishnamurthy ^[2] ; Vincent Jo,Davisson ^[5] ; Sushant Kumar,Shrivastava ^[6]

作者单位： Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology - Banaras Hindu University, Varanasi, 221005, India. ^[1] Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology-Banaras Hindu University, Varanasi, 221005, India. ^[2] Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. ^[3] Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. ^[4] Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. ^[5] Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology - Banaras Hindu University, Varanasi, 221005, India. Electronic address: skshrivastava.phe@itbhu.ac.in. ^[6]

关键词 Acetylcholine esterase (AChE)Alzheimer's disease Amyloid-β Butyrylcholine esterase (BChE)Structure-based drug design β-Secretase-1