Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer.

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第一作者： Daniel J,Turnham

第一单位： The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.

作者： Daniel J,Turnham ^[1] ; Manisha S,Mullen ^[1] ; Nicholas P,Bullock ^[1] ; Kathryn L,Gilroy ^[2] ; Anna E,Richards ^[1] ; Radhika,Patel ^[3] ; Marcos,Quintela ^[1] ; Valerie S,Meniel ^[1] ; Gillian,Seaton ^[1] ; Howard,Kynaston ^[4] ; Richard W E,Clarkson ^[1] ; Toby J,Phesse ^[5] ; Peter S,Nelson ^[6] ; Michael C,Haffner ^[7] ; John N,Staffurth ^[8] ; Helen B,Pearson ^[1]

作者单位： The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK. ^[1] Cancer Research UK Scotland Institute, Glasgow G61 1BD, UK. ^[2] Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. ^[3] Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.;Department of Urology, Cardiff and Vale University Health Board, University Hospital of Wales, Cardiff CF14 4XW, UK. ^[4] The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.;The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia. ^[5] Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.;Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.;Department of Urology, University of Washington, Seattle, WA 98195, USA.;Department of Medicine, University of Washington, Seattle, WA 98195, USA. ^[6] Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.;Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA. ^[7] Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. ^[8]

关键词 androgen receptor (AR)castration-resistant prostate cancer (CRPC)double-negative prostate cancer (DNPC)neuroendocrine (NE)patient-derived xenograft (PDX)

主题词男(雄)性(Male);人类(Humans);动物(Animals);受体, 雄激素(Receptors, Androgen);小鼠(Mice);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);苯硫乙内酰脲(Phenylthiohydantoin);肿瘤转移(Neoplasm Metastasis);腈类(Nitriles);疾病模型, 动物(Disease Models, Animal);苯甲酰胺类(Benzamides);酞嗪类(Phthalazines);哌嗪类(Piperazines)

DOI 10.3390/cells13080673

PMID 38667288

发布时间 2025-01-17

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Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer.

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Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer.

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