A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.

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第一作者： Ellen L,Risemberg

第一单位： Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.

作者： Ellen L,Risemberg ^[1] ; Johanna M,Smeekens ^[2] ; Marta C,Cruz Cisneros ^[3] ; Brea K,Hampton ^[3] ; Pablo,Hock ^[4] ; Colton L,Linnertz ^[4] ; Darla R,Miller ^[4] ; Kelly,Orgel ^[2] ; Ginger D,Shaw ^[5] ; Fernando Pardo Manuel,de Villena ^[5] ; A Wesley,Burks ^[2] ; William,Valdar ^[6] ; Michael D,Kulis ^[7] ; Martin T,Ferris ^[8]

作者单位： Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC. ^[1] Division of Allergy and Immunology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC. ^[2] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC. ^[3] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC. ^[4] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC. ^[5] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: william.valdar@unc.edu. ^[6] Division of Allergy and Immunology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: mkulis@email.unc.edu. ^[7] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: mtferris@email.unc.edu. ^[8]

关键词 C3H CC027 Collaborative Cross Food allergy QTL T cells Themis genetics genotype-phenotype correlation peanut allergy