Autophagy Deregulation in HIV-1-Infected Cells Increases Extracellular Vesicle Release and Contributes to TLR3 Activation.

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第一作者： Catherine,DeMarino

第一单位： Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Discovery Hall Room 182, 10900 University Blvd., Manassas, VA 20110, USA.;Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

作者： Catherine,DeMarino ^[1] ; Maria,Cowen ^[1] ; Anastasia,Williams ^[2] ; Pooja,Khatkar ^[2] ; Fardokht A,Abulwerdi ^[3] ; Lisa,Henderson ^[4] ; Julia,Denniss ^[4] ; Michelle L,Pleet ^[2] ; Delores R,Luttrell ^[4] ; Iosif,Vaisman ^[5] ; Lance A,Liotta ^[6] ; Joseph,Steiner ^[7] ; Stuart F J,Le Grice ^[3] ; Avindra,Nath ^[4] ; Fatah,Kashanchi ^[2]

作者单位： Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Discovery Hall Room 182, 10900 University Blvd., Manassas, VA 20110, USA.;Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. ^[1] Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Discovery Hall Room 182, 10900 University Blvd., Manassas, VA 20110, USA. ^[2] Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA. ^[3] Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. ^[4] Laboratory for Structural Bioinformatics, School of Systems Biology, George Mason University, Manassas, VA 20110, USA. ^[5] Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA. ^[6] Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. ^[7]

关键词 HIV-associated neurocognitive disorder (HAND)autophagy central nervous system (CNS)combined antiretroviral therapy (cART)extracellular vesicles human immunodeficiency virus-1 (HIV-1)

主题词人类(Humans);Toll样受体3(Toll-Like Receptor 3);HIV-1(HIV-1);HIV感染(HIV Infections);自噬(Autophagy);RNA, 病毒(RNA, Viral)

DOI 10.3390/v16040643

PMID 38675983

发布时间 2024-05-21

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