Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis.

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第一作者： Sangkyou,Lee

第一单位： Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

作者： Sangkyou,Lee ^[1] ; Jolanta,Bondaruk ^[1] ; Yishan,Wang ^[2] ; Huiqin,Chen ^[2] ; June Goo,Lee ^[1] ; Tadeusz,Majewski ^[1] ; Rachel D,Mullen ^[3] ; David,Cogdell ^[4] ; Jiansong,Chen ^[2] ; Ziqiao,Wang ^[5] ; Hui,Yao ^[6] ; Pawel,Kus ^[7] ; Joon,Jeong ^[1] ; Ilkyun,Lee ^[1] ; Woonyoung,Choi ^[8] ; Neema,Navai ^[9] ; Charles,Guo ^[1] ; Colin,Dinney ^[9] ; Keith,Baggerly ^[2] ; Cathy,Mendelsohn ^[10] ; David,McConkey ^[8] ; Richard R,Behringer ^[3] ; Marek,Kimmel ^[11] ; Peng,Wei ^[2] ; Bogdan,Czerniak ^[12]

作者单位： Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[1] Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[2] Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[3] Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[4] Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21218, USA. ^[5] Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[6] Department of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland. ^[7] Johns Hopkins Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD 21218, USA. ^[8] Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[9] Department of Urology, Genetics & Development and Pathology, Columbia University, New York, NY 10032, USA. ^[10] Department of Statistics, Rice University, Houston, TX 77005, USA. ^[11] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: bczernia@mdanderson.org. ^[12]

关键词 CP: Cancer bladder cancer field carcinogenesis field effects forerunner genes mucosal microenvironment urothelial differentiation