Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5.

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作者： Miyuki,Natsume ^[1] ; Mariko,Niwa ^[2] ; Sho,Ichikawa ^[1] ; Takuma,Okamoto ^[1] ; Hisazumi,Tsutsui ^[3] ; Daiki,Usukura ^[3] ; Takatsugu,Murata ^[3] ; Ryo,Abe ^[4] ; Motoyuki,Shimonaka ^[5] ; Toshirou,Nishida ^[6] ; Isamu,Shiina ^[3] ; Yuuki,Obata ^[7]

作者单位： Laboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Faculty of Science, Department of Applied Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan. ^[1] Laboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Faculty of Science, Department of Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan. ^[2] Faculty of Science, Department of Applied Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan. ^[3] Tokyo University of Science, Noda, Chiba, Japan. ^[4] Faculty of Science, Department of Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan. ^[5] National Cancer Center Hospital, Chuo-ku, Tokyo, Japan; Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan. ^[6] Laboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. Electronic address: yuobata@ncc.go.jp. ^[7]

关键词 ARF BFA EGFR GEF Golgi/TGN KIT M-COPA MET RTK endoplasmic reticulum

主题词人类(Humans);ADP核糖基化因子(ADP-Ribosylation Factors);内质网(Endoplasmic Reticulum);ADP核糖基化因子1(ADP-Ribosylation Factor 1);布雷菲德菌素A(Brefeldin A);蛋白质转运(Protein Transport)

DOI 10.1016/j.jbc.2024.107327

PMID 38679330

发布时间 2024-07-24

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