rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals.

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作者： Neda,Kathami ^[1] ; Carolina,Moreno-Vicente ^[2] ; Pablo,Martín ^[3] ; Jhonatan A,Vergara-Arce ^[1] ; Raquel,Ruiz-Hernández ^[1] ; Daniela,Gerovska ^[1] ; Ana M,Aransay ^[4] ; Marcos J,Araúzo-Bravo ^[5] ; Sandra,Camarero-Espinosa ^[6] ; Ander,Abarrategi ^[4]

作者单位： Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain. ^[1] POLYMAT, University of the Basque Country (UPV-EHU), 20018, Donostia-San Sebastian, Spain. ^[2] Complutense University of Madrid, 28040, Madrid, Spain. ^[3] Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014, San Sebastián, Spain. ^[4] Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160, Derio, Spain. ^[5] Centro de Investigación Biomedica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. ^[6] Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), 48940, Leioa, Spain. ^[7] IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Spain. ^[8] Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain. aabarrategi@cicbiomagune.es. ^[9] IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Spain. aabarrategi@cicbiomagune.es. ^[10] Regenerative Medicine and Disease Models Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Paseo Miramón, 194, 20014, Donostia, Gipuzkoa, Spain. aabarrategi@cicbiomagune.es. ^[11]

关键词 Adipogenesis Chondrogenesis Differentiation Mesenchymal stem cells Osteogenesis rhBMP-2