The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells.

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作者： Matteo,Bianchi ^[1] ; Christian,Reichen ^[1] ; Amelie,Croset ^[1] ; Stefanie,Fischer ^[1] ; Aline,Eggenschwiler ^[1] ; Yvonne,Grübler ^[1] ; Rajlakshmi,Marpakwar ^[1] ; Thamar,Looser ^[1] ; Patricia,Spitzli ^[1] ; Christel,Herzog ^[1] ; Denis,Villemagne ^[1] ; Dieter,Schiegg ^[1] ; Liridon,Abduli ^[1] ; Chloé,Iss ^[1] ; Alexandra,Neculcea ^[1] ; Marco,Franchini ^[1] ; Tamara,Lekishvili ^[1] ; Simone,Ragusa ^[1] ; Christof,Zitt ^[1] ; Yvonne,Kaufmann ^[1] ; Alienor,Auge ^[1] ; Martin,Hänggi ^[1] ; Waleed,Ali ^[1] ; Teresa M,Frasconi ^[1] ; Stephan,Wullschleger ^[1] ; Iris,Schlegel ^[1] ; Mirela,Matzner ^[1] ; Ursina,Lüthi ^[2] ; Bernd,Schlereth ^[1] ; Keith M,Dawson ^[1] ; Vladimir,Kirkin ^[1] ; Adrian F,Ochsenbein ^[2] ; Sebastian,Grimm ^[1] ; Nina,Reschke ^[1] ; Carsten,Riether ^[2] ; Daniel,Steiner ^[1] ; Nicolas,Leupin ^[1] ; Anne,Goubier ^[1]

作者单位： Molecular Partners AG, Zurich-Schlieren, Switzerland. ^[1] Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. ^[2]

主题词人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);动物(Animals);小鼠(Mice);肿瘤干细胞(Neoplastic Stem Cells);T淋巴细胞(T-Lymphocytes);白细胞介素3受体α亚单位(Interleukin-3 Receptor alpha Subunit);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);细胞系, 肿瘤(Cell Line, Tumor);细胞毒性, 免疫(Cytotoxicity, Immunologic)

DOI 10.1158/2326-6066.CIR-23-0692

PMID 38683145

发布时间 2024-07-12

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Cancer immunology research

2024年12卷7期

921-943页

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The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells.

Cancer immunology research

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Cancer immunology research

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The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells.

Cancer immunology research

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Cancer immunology research

相关期刊

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