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首页> Archives of virology> Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes.

Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes.

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第一作者： Soma,Das

第一单位： Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India. somad@iisc.ac.in.

作者： Soma,Das ^[1] ; Padmanava,Behera ^[2] ; Dipeshwari J,Shewale ^[3] ; Janhavi,Bodele ^[3] ; Saumitra,Das ^[4] ; Anjali A,Karande ^[5]

作者单位： Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India. somad@iisc.ac.in. ^[1] Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India. ^[2] Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India. ^[3] Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.;National Institute of Biomedical Genomics, Kalyani, West Bengal, India. ^[4] Department of Biochemistry, Indian Institute of Science, Bangalore, 560012, India.;Centre For Human Genetics, Biotech Park, Bangalore, 560012, India. ^[5]

关键词 anti-HCV therapy antibody engineering envelope protein hepatitis C virus monoclonal antibody single-chain variable fragment (scFv)

主题词肝炎病毒属(Hepacivirus);单链抗体(Single-Chain Antibodies);肝细胞(Hepatocytes);动物(Animals);人类(Humans);表位(Epitopes);小鼠(Mice);病毒包膜蛋白质类(Viral Envelope Proteins);病毒内化(Virus Internalization);丙型肝炎(Hepatitis C);抗体, 中和(Antibodies, Neutralizing);病毒复制(Virus Replication);抗体, 单克隆(Antibodies, Monoclonal)

DOI 10.1007/s00705-024-06024-4

PMID 38683226

发布时间 2024-05-23

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Archives of virology

Archives of virology

2024年169卷5期

112页

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