A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861.

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作者： Finn J,Schulze ^[1] ; Mazdak,Asadian-Birjand ^[1] ; Michael,Pradela ^[1] ; Nicole,Niesler ^[2] ; Gregor,Nagel ^[1] ; Hendrik,Fuchs ^[1]

作者单位： Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. ^[1] Interfaculty Institute of Biochemistry, University of Tübingen, Auf der Morgenstelle 34, 72076, Tübingen, Germany. ^[2] Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. hendrik.fuchs@charite.de. ^[3]

关键词 Cancer treatment Dianthin Drug delivery Endosomal escape Epidermal growth factor Glycosylated triterpenoid Molecular adapter

主题词人类(Humans);内颗粒(Endosomes);细胞存活(Cell Survival);细胞穿透性肽类(Cell-Penetrating Peptides);三萜类(Triterpenes);细胞系, 肿瘤(Cell Line, Tumor);表皮生长因子(Epidermal Growth Factor)

DOI 10.1186/s12896-024-00854-5

PMID 38685061

发布时间 2024-05-02

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