An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.

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作者： Rachel L,Paterson ^[1] ; Marco P,La Manna ^[2] ; Victoria,Arena De Souza ^[1] ; Andrew,Walker ^[1] ; Dawn,Gibbs-Howe ^[1] ; Rakesh,Kulkarni ^[1] ; Joannah R,Fergusson ^[1] ; Nitha Charles,Mulakkal ^[1] ; Mauro,Monteiro ^[1] ; Wilawan,Bunjobpol ^[1] ; Marcin,Dembek ^[1] ; Magdalena,Martin-Urdiroz ^[1] ; Tressan,Grant ^[1] ; Claire,Barber ^[1] ; Diana J,Garay-Baquero ^[3] ; Liku Bekele,Tezera ^[4] ; David,Lowne ^[1] ; Camille,Britton-Rivet ^[1] ; Robert,Pengelly ^[1] ; Natalia,Chepisiuk ^[1] ; Praveen K,Singh ^[1] ; Amanda P,Woon ^[1] ; Alex S,Powlesland ^[1] ; Michelle L,McCully ^[1] ; Nadia,Caccamo ^[2] ; Mariolina,Salio ^[1] ; Giusto Davide,Badami ^[2] ; Lucy,Dorrell ^[1] ; Andrew,Knox ^[1] ; Ross,Robinson ^[1] ; Paul,Elkington ^[3] ; Francesco,Dieli ^[2] ; Marco,Lepore ^[1] ; Sarah,Leonard ^[1] ; Luis F,Godinho ^[1]

作者单位： Immunocore Ltd., Abingdon, Oxfordshire OX14 4RY, United Kingdom. ^[1] Department of Biomedicine, Neurosciences and Advanced Diagnostic, University of Palermo, Palermo 90127, Italy.;Central Laboratory of Advanced Diagnosis and Biomedical Research, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, University of Palermo, Palermo 90127, Italy. ^[2] National Institute for Health and Care Research, Biomedical Research Centre and Institute for Life Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom. ^[3] Department of Biomedicine, Neurosciences and Advanced Diagnostic, University of Palermo, Palermo 90127, Italy. ^[4]

关键词 HLA-E T cell receptor immunotherapy tuberculosis

主题词结核分枝杆菌(Mycobacterium tuberculosis);人类(Humans);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);T淋巴细胞(T-Lymphocytes);细菌蛋白质类(Bacterial Proteins);结核(Tuberculosis)

DOI 10.1073/pnas.2318003121

PMID 38691588

发布时间 2024-07-24

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准确一般字义偏差语意偏离译文作用小提交