Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease.

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作者： Karina A,Stadler ^[1] ; Lesly J,Ortiz-Joya ^[1] ; Amit,Singh Sahrawat ^[2] ; Christoph,Buhlheller ^[3] ; Karl,Gruber ^[4] ; Tea,Pavkov-Keller ^[5] ; Treasa B,O'Hagan ^[4] ; Alba,Guarné ^[4] ; Sergio,Pulido ^[5] ; Marcel,Marín-Villa ^[6] ; Klaus,Zangger ^[7] ; Nina,Gubensäk ^[4]

作者单位： Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria. ^[1] Programa de Estudio y Control de Enfermedades Tropicales (PECET), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. ^[2] Department of Biochemistry, McGill University, Montreal, Canada. ^[3] Institute of Molecular Biosciences, University of Graz, Graz, Austria. ^[4] Innophore GmbH, Graz, Austria. ^[5] Field of Excellence BioHealth, University of Graz, Graz, Austria. ^[6] BioTechMed-Graz, Graz, Austria. ^[7] LifeFactors ZF SAS, Rionegro, Colombia. ^[8] Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Graz, Austria. klaus.zangger@uni-graz.at. ^[9] Field of Excellence BioHealth, University of Graz, Graz, Austria. klaus.zangger@uni-graz.at. ^[10] BioTechMed-Graz, Graz, Austria. klaus.zangger@uni-graz.at. ^[11] Institute of Molecular Biosciences, University of Graz, Graz, Austria. nina.gubensaek@uni-graz.at. ^[12]

关键词 Akt/PKB American trypanosomiasis NMR PH domain Parasitic disease