Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes.

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第一作者： Hanna,Gruszczynska

第一单位： School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

作者： Hanna,Gruszczynska ^[1] ; Rosemary E,Barnett ^[2] ; Gavin R,Lloyd ^[3] ; Ralf J M,Weber ^[4] ; Thomas N,Lawson ^[2] ; Jiarui,Zhou ^[1] ; Elena,Sostare ^[2] ; John K,Colbourne ^[5] ; Mark R,Viant ^[6]

作者单位： School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. ^[1] Michabo Health Science Limited, Union House, 111 New Union Street, Coventry, CV1 2NT, UK. ^[2] Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. ^[3] School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.;Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. ^[4] School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.;Michabo Health Science Limited, Union House, 111 New Union Street, Coventry, CV1 2NT, UK. ^[5] School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. mark@michabo.co.uk.;Michabo Health Science Limited, Union House, 111 New Union Street, Coventry, CV1 2NT, UK. mark@michabo.co.uk.;Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. mark@michabo.co.uk. ^[6]

关键词 Bioactivity profile-based grouping Bioactivity similarity Multi-omics NAM Omics Replicability confidence

主题词水蚤属(Daphnia);动物(Animals);偶氮化合物(Azo Compounds);着色剂(Coloring Agents);水污染物, 化学性(Water Pollutants, Chemical);代谢组学(Metabolomics);毒性试验(Toxicity Tests)

DOI 10.1007/s00204-024-03759-6

PMID 38695895

发布时间 2024-12-09

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