Monoclonal antibody-mediated neutralization of Clostridioides difficile toxin does not diminish induction of the protective innate immune response to infection.

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作者： Joshua E,Denny ^[1] ; Md Zahidul,Alam ^[1] ; Nontokozo V,Mdluli ^[1] ; Jeffrey R,Maslanka ^[1] ; Linda A,Lieberman ^[2] ; Michael C,Abt ^[3]

作者单位： Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Discovery Immunology, Merck & Co., Inc, Cambridge, MA, USA. ^[2] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Michael.abt@pennmedicine.upenn.edu. ^[3]

关键词 Colitis Immunology Infection Inflammation

主题词动物(Animals);细菌毒素类(Bacterial Toxins);抗体, 单克隆(Antibodies, Monoclonal);免疫, 先天(Immunity, Innate);梭菌感染(Clostridium Infections);小鼠(Mice);肠毒素类(Enterotoxins);疾病模型, 动物(Disease Models, Animal);抗体, 中和(Antibodies, Neutralizing);细菌蛋白质类(Bacterial Proteins);女(雌)性(Female);细胞因子类(Cytokines);小鼠, 近交C57BL(Mice, Inbred C57BL)

DOI 10.1016/j.anaerobe.2024.102859

PMID 38701911

发布时间 2024-08-30

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Monoclonal antibody-mediated neutralization of Clostridioides difficile toxin does not diminish induction of the protective innate immune response to infection.

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Monoclonal antibody-mediated neutralization of Clostridioides difficile toxin does not diminish induction of the protective innate immune response to infection.

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