Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway.

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第一作者： Yue,Zhang

第一单位： Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: Zhangyuee012@163.com.

作者： Yue,Zhang ^[1] ; Di,Wu ^[2] ; Qishun,Sun ^[3] ; Zhen,Luo ^[4] ; Yuhao,Zhang ^[5] ; Bowei,Wang ^[6] ; Wenting,Chen ^[7]

作者单位： Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: Zhangyuee012@163.com. ^[1] Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: wu_d99@163.com. ^[2] Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: sunqishun12345@126.com. ^[3] Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: 1759412783@qq.com. ^[4] Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: 2235599171@qq.com. ^[5] Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: 81297810@qq.com. ^[6] Department of Anesthesiology, Nanfang Hospital, Southern Medical University, The Key Laboratory of Precision Anesthesia & Perioperative Organ Protection, Guangzhou, Guangdong, 510515, China. Electronic address: chenwenting326@126.com. ^[7]

关键词 Atorvastatin ERK Imipenem Lung injury NOX2 Neutrophil extracellular trap Sepsis