Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways.

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作者： Robert A,Gatenby ^[1] ; Kimberly A,Luddy ^[2] ; Jamie K,Teer ^[2] ; Anders,Berglund ^[3] ; Audrey R,Freischel ^[2] ; Ryan M,Carr ^[3] ; Amanda E,Lam ^[4] ; Kenneth J,Pienta ^[5] ; Sarah R,Amend ^[6] ; Robert H,Austin ^[7] ; Emma U,Hammarlund ^[7] ; John L,Cleveland ^[8] ; Kenneth Y,Tsai ^[9] ; Joel S,Brown ^[2]

作者单位： Department of Cancer Biology and Evolution, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA. Robert.gatenby@moffitt.org. ^[1] Department of Cancer Biology and Evolution, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA. ^[2] Department of Bioinformatics, Moffitt Cancer Center, Tampa, USA. ^[3] Cancer Bioengineering Department, University of Texas, Austin, USA. ^[4] Department of Oncology, Mayo Clinic, Rochester, USA. ^[5] Case Western Reserve University, Cleveland, USA. ^[6] Cancer Ecology Program, Johns Hopkins University, Baltimore, USA. ^[7] Department of Physics, Princeton University, Princeton, USA. ^[8] Division of Translational Cancer Research, Lund University, Lund, Sweden. ^[9] Departments of Pathology and Tumor Biology, Moffitt Cancer Center, Tampa, USA. ^[10]

关键词 Cancer ecology Cancer evolution Co-adapted syndromes Driver phenotype Evolutionary triage Lung adenocarcinoma

主题词人类(Humans);肺肿瘤(Lung Neoplasms);突变(Mutation);后成说, 遗传(Epigenesis, Genetic);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);进化, 分子(Evolution, Molecular);肿瘤微环境(Tumor Microenvironment)

DOI 10.1007/s12032-024-02344-2

PMID 38704802

发布时间 2024-06-13

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准确一般字义偏差语意偏离译文作用小提交