Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics.

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作者： Li-Wei,Xie ^[1] ; Shang,Cai ^[1] ; Hai-Yan,Lu ^[1] ; Feng-Ling,Tang ^[1] ; Rui-Qiu,Zhu ^[1] ; Ye,Tian ^[1] ; Ming,Li ^[2]

作者单位： Suzhou Key Laboratory for Radiation Oncology, Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China. ^[1] State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China. ^[2]

关键词 Radiotherapy gastrointestinal tract toxicity gut microbiota indole-3-carboxaldehyde intestinal stem cells tryptophan metabolites

主题词动物(Animals);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);男(雄)性(Male);人类(Humans);有益菌种(Probiotics);受体, 芳基烃(Receptors, Aryl Hydrocarbon);吲哚类(Indoles);辐射防护剂(Radiation-Protective Agents);类器官(Organoids);辐射损伤(Radiation Injuries);肠黏膜(Intestinal Mucosa);肠(Intestines);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors)

DOI 10.1080/19490976.2024.2347722

PMID 38706205

发布时间 2024-08-09

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Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics.

Gut microbes

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Gut microbes

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Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics.

Gut microbes

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Gut microbes

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