Synthesis and antiproliferative evaluation of novel 3,5,8-trisubstituted coumarins against breast cancer.

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第一作者： Manar G,Salem

第一单位： Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

作者： Manar G,Salem ^[1] ; Alaa M,Alqahtani ^[2] ; Suraj N,Mali ^[3] ; Hussah Abdullah,Alshwyeh ^[4] ; Rahul D,Jawarkar ^[5] ; Abdulmalik S,Altamimi ^[6] ; Samar Z,Alshawwa ^[7] ; Ebtesam,Al-Olayan ^[8] ; Essa M,Saied ^[9] ; Mohamed F,Youssef ^[10]

作者单位： Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. ^[1] Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia. ^[2] School of Pharmacy, DY Patil Deemed to be University Sector 7, Nerul, Navi Mumbai, 400706, India. ^[3] Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia. ^[4] Basic & Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University, PO Box 1982, Dammam, 31441, Saudi Arabia. ^[5] Department of Medicinal Chemistry & Drug Discovery, Dr. Rajendra Gode Institute of Pharmacy, University Mardi Road, Amravati, 444603, India. ^[6] Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, PO Box 173, Alkharj, 11942, Saudi Arabia. ^[7] Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, PO Box 84428, Riyadh, 11671, Saudi Arabia. ^[8] Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. ^[9] Chemistry Department (Biochemistry Division), Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt. ^[10] Institute for Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, Berlin, 12489, Germany. ^[11] Chemistry Department (Organic Chemistry Division), Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt. ^[12]

关键词 breast cancer cell cycle distribution cytotoxic activity flow cytometric analysis molecular dynamics molecular modeling programmed cell death substituted coumarins topoisomerase IIβ