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PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses.

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第一作者： Srivatsan,Parthasarathy

第一单位： Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA.

作者： Srivatsan,Parthasarathy ^[1] ; Pradtahna,Saenjamsai ^[1] ; Hongping,Hao ^[1] ; Anna,Ferkul ^[1] ; Jessica J,Pfannenstiel ^[1] ; Daniel S,Bejan ^[2] ; Yating,Chen ^[3] ; Ellen L,Suder ^[4] ; Nancy,Schwarting ^[1] ; Masanori,Aikawa ^[5] ; Elke,Muhlberger ^[4] ; Adam J,Hume ^[4] ; Robin C,Orozco ^[1] ; Christopher S,Sullivan ^[3] ; Michael S,Cohen ^[2] ; David J,Davido ^[1] ; Anthony R,Fehr ^[1]

作者单位： Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA. ^[1] Department of Chemical Physiology and Biochemistry, Oregon Health Sciences University, Portland, OR, 97239, USA. ^[2] Department of Molecular Biosciences, University of Texas, Austin, TX, 78712, USA. ^[3] Department of Microbiology, Boston University School of Medicine, Boston, MA, 02118, USA.;National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, 02118, USA.;Center for Emerging Infectious Diseases Policy & Research, Boston University, Boston, MA, 02118, USA. ^[4] Center for Excellence in Vascular Biology (P.K.J., M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.;Center for Interdisciplinary Cardiovascular Sciences (M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.;Channing Division of Network Medicine (M.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. ^[5]

关键词 ADP-ribosylation Ebola virus HSV-1 LCMV Nipah virus PARP VSV coronavirus interferon interferon-stimulated genes macrodomain

DOI 10.1101/2024.04.26.591186

PMID 38712082

发布时间 2025-10-08

基金项目

P20 GM113117/GM/NIGMS NIH HHS/United States R01 HL126901/HL/NHLBI NIH HHS/United States T32 HL007035/HL/NHLBI NIH HHS/United States R35 GM138029/GM/NIGMS NIH HHS/United States K22 AI134993/AI/NIAID NIH HHS/United States R21 AI169646/AI/NIAID NIH HHS/United States R01 AI123231/AI/NIAID NIH HHS/United States R21 AI173781/AI/NIAID NIH HHS/United States P30 GM145499/GM/NIGMS NIH HHS/United States R01 AI133486/AI/NIAID NIH HHS/United States UC7 AI070088/AI/NIAID NIH HHS/United States

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PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses.

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