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Genome organization around nuclear speckles drives mRNA splicing efficiency.

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第一作者： Prashant,Bhat

第一单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.;David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

作者： Prashant,Bhat ^[1] ; Amy,Chow ^[2] ; Benjamin,Emert ^[2] ; Olivia,Ettlin ^[2] ; Sofia A,Quinodoz ^[3] ; Mackenzie,Strehle ^[2] ; Yodai,Takei ^[2] ; Alex,Burr ^[2] ; Isabel N,Goronzy ^[1] ; Allen W,Chen ^[2] ; Wesley,Huang ^[2] ; Jose Lorenzo M,Ferrer ^[2] ; Elizabeth,Soehalim ^[2] ; Say-Tar,Goh ^[2] ; Tara,Chari ^[2] ; Delaney K,Sullivan ^[1] ; Mario R,Blanco ^[2] ; Mitchell,Guttman ^[4]

作者单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.;David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. ^[2] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.;Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. ^[3] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. mguttman@caltech.edu. ^[4]

医学主题词动物(Animals);人类(Humans);男(雄)性(Male);小鼠(Mice);基因(Genes);基因组(Genome);RNA前体(RNA Precursors);RNA剪接(RNA Splicing);RNA, 信使(RNA, Messenger);剪接体(Spliceosomes);转录, 遗传(Transcription, Genetic)

DOI 10.1038/s41586-024-07429-6

PMID 38720076

发布时间 2024-11-09

基金项目

F30 CA247447/CA/NCI NIH HHS/United States T32 GM007616/GM/NIGMS NIH HHS/United States T32 GM008042/GM/NIGMS NIH HHS/United States U01 DK127420/DK/NIDDK NIH HHS/United States R01 DA053178/DA/NIDA NIH HHS/United States

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