ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment.

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作者： Juan,Zhang ^[1] ; Fan,Ouyang ^[2] ; Anbo,Gao ^[2] ; Tian,Zeng ^[3] ; Ming,Li ^[1] ; Hui,Li ^[4] ; Wenchao,Zhou ^[5] ; Qing,Gao ^[1] ; Xing,Tang ^[1] ; Qunfeng,Zhang ^[4] ; Xiaomin,Ran ^[1] ; Gang,Tian ^[4] ; Xiyun,Quan ^[1] ; Zhenzi,Tang ^[4] ; Juan,Zou ^[6] ; Yifei,Zeng ^[7] ; Yunzhu,Long ^[8] ; Yukun,Li ^[6]

作者单位： Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. ^[1] Department of Cardiology, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. ^[2] Clinical Research Institute, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. ^[3] Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China. ^[4] Trauma Center, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. ^[5] Department of Gynecologic Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. ^[6] Department of Rehabilitation, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. ^[7] Department of Pathology, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. ^[8] Department of Oncology, Shenzhen Luohu People's Hospital, Shenzhen, Guangdong, China. yifei916@163.com. ^[9] Department of Infectious Disease, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. 2863454482@qq.com. ^[10] Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. yukun_li@foxmail.com. ^[11]

关键词 ESM1 Ovarian cancer PKM2 SUMOylation Tumor metabolic reprogramming Vascular mimicry