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首页> Frontiers in immunology> Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization.

Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization.

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作者： Heleen,Hanssens ^[1] ; Fien,Meeus ^[2] ; Yannick,De Vlaeminck ^[3] ; Quentin,Lecocq ^[2] ; Janik,Puttemans ^[2] ; Pieterjan,Debie ^[2] ; Timo W M,De Groof ^[1] ; Cleo,Goyvaerts ^[1] ; Kim,De Veirman ^[1] ; Karine,Breckpot ^[2] ; Nick,Devoogdt ^[3]

作者单位： Laboratory of Molecular Imaging and Therapy (MITH), Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium. ^[1] Laboratory for Molecular and Cellular Therapy (LMCT), Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium. ^[2] Laboratory for Hematology and Immunology (HEIM), Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium. ^[3]

关键词 CAR-T cells VHH adoptive cell transfer hematology multiple myeloma

主题词多发性骨髓瘤(Multiple Myeloma);人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);小鼠(Mice);淋巴细胞活化(Lymphocyte Activation);T淋巴细胞(T-Lymphocytes);单链抗体(Single-Chain Antibodies);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.3389/fimmu.2024.1389018

PMID 38720898

发布时间 2024-05-10

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Frontiers in immunology

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