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Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.

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第一作者: Tamara,Kögl
第一单位: Institute for Immunology, Center for Microbiology and Hygiene, Medical Center-University of Freiburg , Freiburg, Germany.;Faculty of Medicine, Institute for Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.
作者单位: Institute for Immunology, Center for Microbiology and Hygiene, Medical Center-University of Freiburg , Freiburg, Germany.;Faculty of Medicine, Institute for Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany. [1] Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, Saarland University , Homburg, Germany. [2] Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center- University of Freiburg, Freiburg, Germany. [3] Division of Bone Marrow Transplantation and Immune Deficiency, and Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.;Department of Medicine, Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. [4] Faculty of Medicine, Institute for Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany. [5] Faculty of Medicine, Institute for Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany. [6] Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, Institute for Transfusion Medicine and Gene Therapy-University of Freiburg, Freiburg, Germany. [7] Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.;Faculty of Medicine, Institute for Transfusion Medicine and Gene Therapy-University of Freiburg, Freiburg, Germany. [8] Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. [9] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.;Imagine Institute, University of Paris-Cité , Paris, France.;St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. [10] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.;Imagine Institute, University of Paris-Cité , Paris, France. [11] Division of Rheumatology and Immunology, Medical University of Graz, Graz, Austria. [12] Department of Urology, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany. [13] Institute of Medical Microbiology and Hygiene, University Medical Center , Freiburg, Germany. [14] Department of Pathology, Institute of Surgical Pathology, University Medical Center, University of Freiburg, Freiburg, Germany. [15] Department of Medicine, Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. [16] Institute for Immunology, Center for Microbiology and Hygiene, Medical Center-University of Freiburg , Freiburg, Germany. [17] Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [18] Department of Microbiology, Immunology, and Transplantation, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium.;Dr. Shahrooei Laboratory, Tehran University of Medical Sciences, Tehran, Iran. [19] Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.;Research Center for Immunodeficiencies, Tehran University of Medical Sciences , Tehran, Iran. [20] Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Faculty for Medicine, Center for Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Freiburg, Germany. [21] Faculty of Medicine, Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Freiburg, Germany.;Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center- University of Freiburg, Freiburg, Germany.;Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.;Centre for Integrative Biological Signalling Studies, University of Freiburg , Freiburg, Germany.;Faculty of Medicine, Clinical Immunology, Medical Center-University of Freiburg, Freiburg, Germany. [22] Department of Medicine, Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.;Division of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.;Broegelmann Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway. [23]
DOI 10.1084/jem.20221122
PMID 38722309
发布时间 2024-06-05
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