首页> International journal of molecular sciences> Modulating Endoplasmic Reticulum Chaperones and Mutant Protein Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with Febrile Seizures Plus and Dravet Syndrome.

Modulating Endoplasmic Reticulum Chaperones and Mutant Protein Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with Febrile Seizures Plus and Dravet Syndrome.

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第一作者： Sarah,Poliquin

第一单位： Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA.;Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.

作者： Sarah,Poliquin ^[1] ; Gerald,Nwosu ^[2] ; Karishma,Randhave ^[3] ; Wangzhen,Shen ^[3] ; Carson,Flamm ^[3] ; Jing-Qiong,Kang ^[4]

作者单位： Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA.;Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA. ^[1] Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.;Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.;Department of Neurology, Vanderbilt University Medical Center, 465 21st Ave South, Nashville, TN 37232, USA. ^[2] Department of Neurology, Vanderbilt University Medical Center, 465 21st Ave South, Nashville, TN 37232, USA. ^[3] Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.;Department of Neurology, Vanderbilt University Medical Center, 465 21st Ave South, Nashville, TN 37232, USA.;Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.;Vanderbilt Kennedy Center of Human Development, Vanderbilt University, Nashville, TN 37232, USA. ^[4]

关键词 Dravet syndrome E3 ubiquitin ligase GABAA receptor endoplasmic-reticulum-associated protein degradation (ERAD)epilepsy intracellular trafficking proteostasis