The Association between PDE5 Inhibitors and Aneurysm/Arterial Dissection:A Pharmacovigilance Study Using WHO Safety Database.

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作者： Koji,Miyata ^[1] ; Yuki,Izawa-Ishizawa ^[2] ; Takahiro,Niimura ^[3] ; Hirofumi,Hamano ^[4] ; Fuka,Aizawa ^[5] ; Kenta,Yagi ^[3] ; Kei,Kawada ^[6] ; Yoshito,Zamami ^[7] ; Mitsuhiro,Goda ^[5] ; Keisuke,Ishizawa ^[8]

作者单位： Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan. ^[1] Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.;Department of General Medicine, Taoka Hospital, Tokushima, Japan. ^[2] Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.;Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan. ^[3] Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.;Department of Pharmacy, Okayama University Hospital, Okayama, Japan. ^[4] Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.;Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan. ^[5] Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.;Department of Clinical Pharmacy Practice Pedagogy, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan. ^[6] Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.;Department of Pharmacy, Okayama University Hospital, Okayama, Japan. ^[7] Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.;Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.;Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan. ^[8]

关键词 Adverse event Aneurysm Arterial dissection PDE5 inhibitors Pharmacovigilance