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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response.

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作者单位: Centre for Human Genetics, University of Oxford, Oxford, UK. alexander.mentzer@ndm.ox.ac.uk.;Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. alexander.mentzer@ndm.ox.ac.uk. [1] Centre for Human Genetics, University of Oxford, Oxford, UK.;Institute of Medical Microbiology and Hospital Hygiene, University Hospital of Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.;Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, Bethesda, MD, USA. [2] Wellcome Sanger Institute, Cambridge, UK. [3] Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda. [4] South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa. [5] Groupe de Recherche Action en Santé (GRAS) 06 BP 10248, Ouagadougou, Burkina Faso. [6] Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. [7] National Institute for Public Health and the Environment, Bilthoven, The Netherlands. [8] Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK. [9] Histogenetics, New York, USA. [10] Centre for Human Genetics, University of Oxford, Oxford, UK. [11] Department of Integrative Biology, University of California at Berkeley, California, CA, USA. [12] Avon Longitudinal Study of Parents and Children at University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. [13] Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.;MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. [14] Centre for Human Genetics, University of Oxford, Oxford, UK.;Department of Infectious Disease, Imperial College London, London, UK. [15] The Jenner Institute, University of Oxford, Oxford, UK. [16] Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.;The Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine London, London, UK. [17] MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine London, London, UK. [18] Tissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [19] Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.;Radcliffe Department of Medicine, University of Oxford, Oxford, UK. [20] Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.;Department of Medicine, University of California, San Diego, La Jolla, CA, USA. [21] Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.;MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine London, London, UK. [22] Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. [23] Centre for Human Genetics, University of Oxford, Oxford, UK.;The Jenner Institute, University of Oxford, Oxford, UK. [24] Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK. m.sandhu@imperial.ac.uk. [25]
DOI 10.1038/s41591-024-02944-5
PMID 38740997
发布时间 2024-11-27
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