High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response.
作者:
Alexander J,Mentzer [1]
;
Alexander T,Dilthey [2]
;
Martin,Pollard [3]
;
Deepti,Gurdasani [3]
;
Emre,Karakoc [3]
;
Tommy,Carstensen [3]
;
Allan,Muhwezi [4]
;
Clare,Cutland [5]
;
Amidou,Diarra [6]
;
Ricardo,da Silva Antunes [7]
;
Sinu,Paul [7]
;
Gaby,Smits [8]
;
Susan,Wareing [9]
;
HwaRan,Kim [10]
;
Cristina,Pomilla [3]
;
Amanda Y,Chong [11]
;
Debora Y C,Brandt [12]
;
Rasmus,Nielsen [12]
;
Samuel,Neaves [13]
;
Nicolas,Timpson [14]
;
Austin,Crinklaw [7]
;
Cecilia S,Lindestam Arlehamn [7]
;
Anna,Rautanen [11]
;
Dennison,Kizito [4]
;
Tom,Parks [15]
;
Kathryn,Auckland [11]
;
Kate E,Elliott [11]
;
Tara,Mills [11]
;
Katie,Ewer [16]
;
Nick,Edwards [16]
;
Segun,Fatumo [17]
;
Emily,Webb [18]
;
Sarah,Peacock [19]
;
Katie,Jeffery [20]
;
Fiona R M,van der Klis [8]
;
Pontiano,Kaleebu [4]
;
Pandurangan,Vijayanand [7]
;
Bjorn,Peters [21]
;
Alessandro,Sette [21]
;
Nezih,Cereb [10]
;
Sodiomon,Sirima [6]
;
Shabir A,Madhi [5]
;
Alison M,Elliott [22]
;
Gil,McVean [23]
;
Adrian V S,Hill [24]
;
Manjinder S,Sandhu [25]
作者单位:
Centre for Human Genetics, University of Oxford, Oxford, UK. alexander.mentzer@ndm.ox.ac.uk.;Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. alexander.mentzer@ndm.ox.ac.uk.
[1]
Centre for Human Genetics, University of Oxford, Oxford, UK.;Institute of Medical Microbiology and Hospital Hygiene, University Hospital of Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.;Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, Bethesda, MD, USA.
[2]
Wellcome Sanger Institute, Cambridge, UK.
[3]
Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
[4]
South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
[5]
Groupe de Recherche Action en Santé (GRAS) 06 BP 10248, Ouagadougou, Burkina Faso.
[6]
Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
[7]
National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
[8]
Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.
[9]
Histogenetics, New York, USA.
[10]
Centre for Human Genetics, University of Oxford, Oxford, UK.
[11]
Department of Integrative Biology, University of California at Berkeley, California, CA, USA.
[12]
Avon Longitudinal Study of Parents and Children at University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
[13]
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.;MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
[14]
Centre for Human Genetics, University of Oxford, Oxford, UK.;Department of Infectious Disease, Imperial College London, London, UK.
[15]
The Jenner Institute, University of Oxford, Oxford, UK.
[16]
Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.;The Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine London, London, UK.
[17]
MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine London, London, UK.
[18]
Tissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
[19]
Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.;Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
[20]
Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.;Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
[21]
Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.;MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine London, London, UK.
[22]
Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
[23]
Centre for Human Genetics, University of Oxford, Oxford, UK.;The Jenner Institute, University of Oxford, Oxford, UK.
[24]
Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK. m.sandhu@imperial.ac.uk.
[25]
主题词
女(雌)性(Female);人类(Humans);婴儿(Infant);男(雄)性(Male);抗体生成(Antibody Formation);乙型肝炎疫苗(Hepatitis B Vaccines);百日咳菌苗(Pertussis Vaccine);数量性状基因座位(Quantitative Trait Loci);乌干达(Uganda);接种(Vaccination);百日咳(Whooping Cough);布基纳法索(Burkina Faso);南非(South Africa)
DOI
10.1038/s41591-024-02944-5
PMID
38740997
发布时间
2024-11-27
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Nature medicine
Nature medicine
1384-1394页
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