Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with abnormalities in white matter structural integrity and connectivity: An ex-vivo diffusion MRI and pathology investigation.

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作者： Mahir,Tazwar ^[1] ; Arnold M,Evia ^[2] ; Abdur Raquib,Ridwan ^[2] ; Sue E,Leurgans ^[3] ; David A,Bennett ^[3] ; Julie A,Schneider ^[4] ; Konstantinos,Arfanakis ^[5]

作者单位： Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA. ^[1] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. ^[2] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. ^[3] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA. ^[4] Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, USA. Electronic address: konstantinos_arfanakis@rush.edu. ^[5]

关键词 Diffusion Tensor Imaging (DTI)Graph theory Limbic predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC)Neuropathology Transactive response DNA binding protein of 43 kDa (TDP-43)White matter (WM) structure and connectivity