Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model.

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第一作者： Toshiaki,Tsuchitani

第一单位： iHuman Institute, ShanghaiTech University, Shanghai, China.;Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, School of Pharmacy, Josai International University (JIU), Tokyo, Japan.

作者： Toshiaki,Tsuchitani ^[1] ; Atsuko,Tomaru ^[2] ; Yasunori,Aoki ^[3] ; Naoki,Ishiguro ^[4] ; Yasuhiro,Tsuda ^[5] ; Yuichi,Sugiyama ^[1]

作者单位： iHuman Institute, ShanghaiTech University, Shanghai, China.;Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, School of Pharmacy, Josai International University (JIU), Tokyo, Japan. ^[1] Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, School of Pharmacy, Josai International University (JIU), Tokyo, Japan. ^[2] Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, School of Pharmacy, Josai International University (JIU), Tokyo, Japan.;Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. ^[3] Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Hyogo, Japan. ^[4] Clinical Pharmacology Department, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Hyogo, Japan. ^[5]

主题词人类(Humans);模型, 生物学(Models, Biological);肝细胞(Hepatocytes);血管紧张素Ⅱ1型受体拮抗剂(Angiotensin II Type 1 Receptor Blockers);肝(Liver);非线性动力学(Nonlinear Dynamics);苯咪唑类(Benzimidazoles);苯甲酸盐类(Benzoates);投药, 口服(Administration, Oral)

DOI 10.1002/psp4.13154

PMID 38745377

发布时间 2024-08-12

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CPT: pharmacometrics & systems pharmacology

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2024年13卷7期

1224-1237页

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Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model.

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Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model.

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