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RACER-m leverages structural features for sparse T cell specificity prediction.

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第一作者： Ailun,Wang

第一单位： Center for Theoretical Biological Physics, Northeastern University, Boston, MA, USA.;Department of Physics, Northeastern University, Boston, MA, USA.

作者： Ailun,Wang ^[1] ; Xingcheng,Lin ^[2] ; Kevin Ng,Chau ^[1] ; José N,Onuchic ^[3] ; Herbert,Levine ^[4] ; Jason T,George ^[5]

作者单位： Center for Theoretical Biological Physics, Northeastern University, Boston, MA, USA.;Department of Physics, Northeastern University, Boston, MA, USA. ^[1] Department of Physics, North Carolina State University, Raleigh, NC, USA.;Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA. ^[2] Departments of Physics and Astronomy, Chemistry, and Biosciences, Rice University, Houston, TX, USA.;Center for Theoretical Biological Physics, Rice University, Houston, TX, USA. ^[3] Center for Theoretical Biological Physics, Northeastern University, Boston, MA, USA.;Department of Physics, Northeastern University, Boston, MA, USA.;Department of Bioengineering, Northeastern University, Boston, MA, USA. ^[4] Center for Theoretical Biological Physics, Rice University, Houston, TX, USA.;Department of Biomedical Engineering, Texas A&M University, Houston, TX, USA. ^[5]

医学主题词受体, 抗原, T细胞(Receptors, Antigen, T-Cell);T淋巴细胞(T-Lymphocytes);人类(Humans);蛋白质结合(Protein Binding);模型, 分子(Models, Molecular);肽类(Peptides);T细胞抗原受体特异性(T-Cell Antigen Receptor Specificity);蛋白质构象(Protein Conformation)

DOI 10.1126/sciadv.adl0161

PMID 38748791

发布时间 2026-01-27

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