Lipoxin A<sub>4</sub> ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes.

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作者： Zhehan,Hu ^[1] ; Liang,Chen ^[1] ; Jihui,Zhao ^[1] ; Weiming,Zhang ^[1] ; Zhuangzhuang,Jin ^[2] ; Yuhan,Sun ^[3] ; Zihan,Li ^[3] ; Bohan,Chang ^[4] ; Peng,Shen ^[1] ; Yue,Yang ^[5]

作者单位： Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, ShenYang, Liaoning, China. ^[1] Department of Emergency Medicine, Shengjing Hospital of China Medical University, ShenYang, Liaoning, China. ^[2] China Medical University, ShenYang, Liaoning, China. ^[3] Department of Rheumatology, The First Afﬁliated Hospital of China Medical University, Shenyang, Liaoning, China. ^[4] Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, ShenYang, Liaoning, China. Electronic address: yueyang@cmu.edu.cn. ^[5]

关键词 Estrogen receptor beta Ferroptosis Fibroblast-like synoviocyte Lipoxin A(4)Lysophosphatidic acid receptor-3 Osteoarthritis

主题词动物(Animals);骨关节炎, 膝(Osteoarthritis, Knee);大鼠(Rats);脂氧素类(Lipoxins);NF-E2相关因子2(NF-E2-Related Factor 2);人类(Humans);男(雄)性(Male);疾病模型, 动物(Disease Models, Animal);成纤维细胞(Fibroblasts);信号传导(Signal Transduction);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);滑膜(Synovial Membrane);疾病恶化(Disease Progression)

DOI 10.1016/j.redox.2024.103143

PMID 38754271

发布时间 2024-09-18

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Redox biology

2024年73卷

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Lipoxin A<sub>4</sub> ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes.

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Lipoxin A<sub>4</sub> ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes.

Redox biology

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Redox biology

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