Androcin 18-1, a novel scorpion-venom peptide, shows a potent antitumor activity against human U87 cells via inducing mitochondrial dysfunction.

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作者： Kai,Wang ^[1] ; Tienthanh,Nguyen ^[2] ; Yihan,Gao ^[1] ; Ruiyin,Guo ^[2] ; Chaofan,Fan ^[1] ; Hang,Liao ^[2] ; Jiali,Li ^[2] ; Jinwei,Chai ^[1] ; Xueqing,Xu ^[3] ; Yuxin,Gong ^[4] ; Xin,Chen ^[5]

作者单位： Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China. ^[1] Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515, Guangzhou, China. ^[2] Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515, Guangzhou, China. Electronic address: xu2003@smu.edu.cn. ^[3] Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China. Electronic address: 2036437@qq.com. ^[4] Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China. Electronic address: chen_xin1020@163.com. ^[5]

关键词 Androcin 18?1 Anticancer peptide Membranolysis Mitochondrial dysfunction