A prognostic neural epigenetic signature in high-grade glioma.-论文-万方医学网

第一作者： Richard,Drexler

第一单位： Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Department of Neurology, Stanford University, Stanford, CA, USA.

作者： Richard,Drexler ^[1] ; Robin,Khatri ^[2] ; Thomas,Sauvigny ^[3] ; Malte,Mohme ^[3] ; Cecile L,Maire ^[3] ; Alice,Ryba ^[3] ; Yahya,Zghaibeh ^[3] ; Lasse,Dührsen ^[3] ; Amanda,Salviano-Silva ^[3] ; Katrin,Lamszus ^[3] ; Manfred,Westphal ^[3] ; Jens,Gempt ^[3] ; Annika K,Wefers ^[4] ; Julia E,Neumann ^[5] ; Helena,Bode ^[6] ; Fabian,Hausmann ^[2] ; Tobias B,Huber ^[7] ; Stefan,Bonn ^[2] ; Kerstin,Jütten ^[8] ; Daniel,Delev ^[9] ; Katharina J,Weber ^[10] ; Patrick N,Harter ^[11] ; Julia,Onken ^[12] ; Peter,Vajkoczy ^[12] ; David,Capper ^[13] ; Benedikt,Wiestler ^[14] ; Michael,Weller ^[15] ; Berend,Snijder ^[16] ; Alicia,Buck ^[15] ; Tobias,Weiss ^[15] ; Pauline C,Göller ^[17] ; Felix,Sahm ^[17] ; Joelle Aline,Menstel ^[18] ; David Niklas,Zimmer ^[18] ; Michael B,Keough ^[19] ; Lijun,Ni ^[19] ; Michelle,Monje ^[19] ; Dana,Silverbush ^[20] ; Volker,Hovestadt ^[21] ; Mario L,Suvà ^[22] ; Saritha,Krishna ^[23] ; Shawn L,Hervey-Jumper ^[23] ; Ulrich,Schüller ^[24] ; Dieter H,Heiland ^[25] ; Sonja,Hänzelmann ^[26] ; Franz L,Ricklefs ^[27]

作者单位： Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Department of Neurology, Stanford University, Stanford, CA, USA. ^[1] Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[2] Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[3] Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[4] Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Center for Molecular Neurobiology Hamburg (ZMNH), University Hospital Hamburg Eppendorf, Hamburg, Germany. ^[5] Research Institute Children's Cancer Center Hamburg, Hamburg, Germany. ^[6] III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[7] Department of Neurosurgery, University Hospital Aachen, Aachen, Germany. ^[8] Department of Neurosurgery, University Hospital Aachen, Aachen, Germany.;Department of Neurosurgery, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany. ^[9] Neurological Institute (Edinger Institute), University Hospital Frankfurt, Frankfurt am Main, Germany.;German Cancer Consortium (DKTK), Heidelberg, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany.;Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.;University Cancer Center (UCT) Frankfurt, Frankfurt am Main, Germany. ^[10] Neurological Institute (Edinger Institute), University Hospital Frankfurt, Frankfurt am Main, Germany.;Institute of Neuropathology, Faculty of Medicine, LMU Munich, Munich, Germany. ^[11] Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany. ^[12] Department of Neuropathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ^[13] Department of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University Munich, Munich, Germany. ^[14] Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.;Department of Neurology, University of Zürich, Zurich, Switzerland. ^[15] Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. ^[16] Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.;Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany. ^[17] Department of Neurosurgery, Medical Center University of Freiburg, Freiburg, Germany. ^[18] Department of Neurology, Stanford University, Stanford, CA, USA. ^[19] Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[20] Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[21] Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. ^[22] Department of Neurological Surgery, University of California, San Francisco, CA, USA. ^[23] Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.;Department of Pediatric Hematology and Oncology, Research Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[24] Department of Neurosurgery, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.;Department of Neurosurgery, Medical Center University of Freiburg, Freiburg, Germany.;Translational Neurosurgery, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.;Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany. ^[25] Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[26] Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. f.ricklefs@uke.de. ^[27]

医学主题词人类(Humans);后成说, 遗传(Epigenesis, Genetic);预后(Prognosis);神经胶质瘤(Glioma);脑肿瘤(Brain Neoplasms);DNA甲基化(DNA Methylation);动物(Animals);小鼠(Mice);男(雄)性(Male);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);胶质母细胞瘤(Glioblastoma);中年人(Middle Aged);神经元(Neurons);成年人(Adult);单细胞分析(Single-Cell Analysis);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1038/s41591-024-02969-w

PMID 38760585

发布时间 2026-06-18

基金项目

R01NS092597/U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 310030 185155/1/Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) DP1 NS111132/NS/NINDS NIH HHS/United States R01 NS092597/NS/NINDS NIH HHS/United States R21 CA264339/CA/NCI NIH HHS/United States HE 8145/6-1/Deutsche Forschungsgemeinschaft (German Research Foundation) 74259/Robert Wood Johnson Foundation (RWJF) SFB 824 B12/Deutsche Forschungsgemeinschaft (German Research Foundation) K08NS110919/U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) R01CA258384/U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) K08 NS110919/NS/NINDS NIH HHS/United States HE 8145/5-1/Deutsche Forschungsgemeinschaft (German Research Foundation) U19 CA264504/CA/NCI NIH HHS/United States R01 CA258384/CA/NCI NIH HHS/United States U19CA264504/U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) SFB 1389/Deutsche Forschungsgemeinschaft (German Research Foundation) P50 CA097257/CA/NCI NIH HHS/United States SFB 1192 B8/Deutsche Forschungsgemeinschaft (German Research Foundation) DFG RI2616/3-1/Deutsche Forschungsgemeinschaft (German Research Foundation) R01 NS137950/NS/NINDS NIH HHS/United States SFB 1192 C3/Deutsche Forschungsgemeinschaft (German Research Foundation) P50 CA165962/CA/NCI NIH HHS/United States P50CA097257/U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics)

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A prognostic neural epigenetic signature in high-grade glioma.

Nature medicine

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A prognostic neural epigenetic signature in high-grade glioma.

Nature medicine

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Nature medicine

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