Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB.

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作者： Qi,Liu ^[1] ; Yajuan,Zhang ^[2] ; Huimin,Li ^[3] ; Hong,Gao ^[4] ; Yijie,Zhou ^[5] ; Dakui,Luo ^[5] ; Zezhi,Shan ^[1] ; Yufei,Yang ^[2] ; Junyong,Weng ^[1] ; Qingguo,Li ^[2] ; Weiwei,Yang ^[1] ; Xinxiang,Li ^[2]

作者单位： Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. ^[1] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. ^[2] Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. ^[3] Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China. ^[4] State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. ^[5] Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China. wyang@sibcb.ac.cn. ^[6] State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. wyang@sibcb.ac.cn. ^[7] Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. xinxiangli@fudan.edu.cn. ^[8] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. xinxiangli@fudan.edu.cn. ^[9]

关键词 (S)-2,3-epoxysqualene Chemoretherapy Colorectal cancer NF-κB pathway Squalene epoxidase