首页> Molecular therapy. Nucleic acids> CRISPR-based editing strategies to rectify <i>EYA1</i> complex genomic rearrangement linked to haploinsufficiency.

CRISPR-based editing strategies to rectify <i>EYA1</i> complex genomic rearrangement linked to haploinsufficiency.

导出 OA

翻译打印收藏纠错

第一作者： Hwalin,Yi

第一单位： Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.

作者： Hwalin,Yi ^[1] ; Yejin,Yun ^[2] ; Won Hoon,Choi ^[2] ; Hye-Yeon,Hwang ^[1] ; Ju Hyuen,Cha ^[2] ; Heeyoung,Seok ^[3] ; Jae-Jin,Song ^[4] ; Jun Ho,Lee ^[2] ; Sang-Yeon,Lee ^[5] ; Daesik,Kim ^[1]

作者单位： Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea. ^[1] Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, South Korea. ^[2] Department of Transdisciplinary Research and Collaboration, Genomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, South Korea. ^[3] Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea. ^[4] Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, South Korea.;Department of Genomic Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.;Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea. ^[5]

关键词 CRISPRa Cas9 EYA1 MT: RNA/DNA Editing chromosomal rearrangement haploinsufficiency pathogenic structure variations

DOI 10.1016/j.omtn.2024.102199

PMID 38766525

发布时间 2024-05-21

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交