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首页> Proceedings of the National Academy of Sciences of the United States of America> Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors.

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors.

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作者： Elie,Adam ^[1] ; Marek,Kowalski ^[2] ; Oluwaseun,Akeju ^[3] ; Earl K,Miller ^[4] ; Emery N,Brown ^[5] ; Michelle M,McCarthy ^[2] ; Nancy,Kopell ^[2]

作者单位： Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.;Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114. ^[1] Department of Mathematics and Statistics, Boston University, Boston, MA 02215. ^[2] Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114.;Department of Anesthesia, Harvard Medical School, Boston, MA 02215. ^[3] Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139. ^[4] Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.;Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114.;Department of Anesthesia, Harvard Medical School, Boston, MA 02215. ^[5]

关键词 NMDA-receptor antagonism antidepressant effect biophysical mechanisms gamma oscillations slow-delta oscillations

主题词氯胺酮(Ketamine);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);动物(Animals);人类(Humans);动力学(Kinetics);脑电描记术(Electroencephalography);兴奋性氨基酸拮抗剂(Excitatory Amino Acid Antagonists);模型, 神经学(Models, Neurological)

DOI 10.1073/pnas.2402732121

PMID 38768339

发布时间 2024-11-21

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2024年121卷22期

e2402732121页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

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